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<a href='https://feeble-allspice.blogspot.com/2013/02/adele-miserables-cast-sing-on-oscar.html'>Adele, 'Les Miserables' cast sing on Oscar stage</a>
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<p class="first">LOS ANGELES (AP) ? It was an extra starry, musical day at the <span class="yshortcuts" id="lw_1361585346278_1">Dolby Theatre</span>.</p> <p>Adele took the stage first Friday, followed by the cast of "Les Miserables," singing together of the first time.</p> <p>Oscar nominees <span class="yshortcuts" id="lw_1361585346278_5">Hugh Jackman</span> and <span class="yshortcuts" id="lw_1361585346278_2">Anne Hathaway</span>, along with co-stars <span class="yshortcuts" id="lw_1361585346278_6">Russell Crowe</span>, <span class="yshortcuts" id="lw_1361585346278_3">Amanda Seyfried</span>, Helena Bonham-Carter, <span class="yshortcuts" id="lw_1361585346278_8">Sasha Baron-Cohen</span>, <span class="yshortcuts" id="lw_1361585346278_7">Eddie Redmayne</span>, <span class="yshortcuts" id="lw_1361585346278_9">Aaron Tveit</span> and <span class="yshortcuts" id="lw_1361585346278_4">Samantha Barks</span> rehearsed their performances on the Oscar stage. They were backed by members of the musical's stage productions from London and Broadway.</p> <p>"Les Miserables" director Tom Hooper sat in the front row of the theater as his cast sang together on stage.</p> <p>Moments earlier, Adele dazzled the tiny audience of show workers with her performance of the James Bond theme "Skyfall."</p> <p>She giddily remarked, "We're seated in the front row!"</p><p>Source: <a href="http://news.yahoo.com/adele-les-miserables-cast-sing-oscar-stage-020713244.html">http://news.yahoo.com/adele-les-miserables-cast-sing-oscar-stage-020713244.html</a></p><p><a href="http://www.virtualurth.com/index.php/member/120017/">Star Wars Episode 7</a> <a href="http://www.myeclipseide.com/user.php?op=userinfo&uname=regioscast">luke bryan</a> <a href="http://baijia.info/member.php?action=profile&uid=63378">NBA</a> <a href="http://mbdefault.org/forum/member.php?action=profile&uid=30232">jfk airport</a> <a href="http://www.spidean.com/user.php?op=userinfo&uname=regioscast">faith hill</a> <a href="http://www.nameslot.com/member.php?action=profile&uid=13708">metro north</a> <a href="http://www.fortunesalwayshiding.net/forum/member.php?action=profile&uid=83946">taco bell</a> </p>
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<a href='https://feeble-allspice.blogspot.com/2013/02/osborne-says-aaa-downgrade-is-reminder.html'>Osborne says AAA downgrade is reminder of debt problems</a>
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<p class="description">* Rafael and Giggs on target for United * Cazorla double gives Arsenal victory * Wigan beat Reading in relegation battle (Adds details, quotes) LONDON, Feb 23 (Reuters) - Leaders Manchester United moved closer to a 20th title and pushed Queens Park Rangers nearer to relegation when goals from Rafael and Ryan Giggs gave them a 2-0 win at the bottom side in the Premier League on Saturday. The victory put United 15 points clear of champions Manchester City who face third-placed Chelsea at home on Sunday. ...</p><p>Source: <a href="http://news.yahoo.com/osborne-says-aaa-downgrade-reminder-debt-problems-221715863--finance.html">http://news.yahoo.com/osborne-says-aaa-downgrade-reminder-debt-problems-221715863--finance.html</a></p><p><a href="http://www.virtualurth.com/index.php/member/120017/">andrew brietbart</a> <a href="http://www.myeclipseide.com/user.php?op=userinfo&uname=regioscast">branson mo</a> <a href="http://baijia.info/member.php?action=profile&uid=63378">monkees songs</a> <a href="http://mbdefault.org/forum/member.php?action=profile&uid=30232">rail gun</a> <a href="http://www.spidean.com/user.php?op=userinfo&uname=regioscast">harrisburg</a> <a href="http://www.nameslot.com/member.php?action=profile&uid=13708">top chef texas</a> <a href="http://www.fortunesalwayshiding.net/forum/member.php?action=profile&uid=83946">great pacific garbage patch</a> </p>
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<a href='https://feeble-allspice.blogspot.com/2013/02/flipping-switch-on-cell-growth-protein.html'>Flipping the 'off' switch on cell growth: Protein uses multiple means to help cells cope when oxygen runs low</a>
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<p id="first"><span class="date">Feb. 22, 2013</span> ? A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying -- known as DNA replication -- and new cell growth to many of the body's functions and in such diseases as cancer.</p> <p>"We've long known that this protein, HIF-1?, can switch hundreds of genes on or off in response to low oxygen conditions," says Gregg Semenza, M.D., Ph.D., a molecular biologist who led the research team and has long studied the role of low-oxygen conditions in cancer, lung disease and heart disorders. "We've now learned that HIF-1? is even more versatile than we thought, as it can work directly to stop new cells from forming." A report on the discovery appears in the Feb. 12 issue of <em>Science Signaling</em>.</p> <p>With his team, Semenza, who is the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University School of Medicine's Institute for Cell Engineering and Institute for Genomic Medicine, discovered HIF-1? in the 1990s and has studied it ever since, pinpointing a multitude of genes in different types of cells that have their activity ramped up or down by the activated protein. These changes in so-called "gene expression" help cells survive when oxygen-rich blood flow to an area slows or stops temporarily; they also allow tumors to build new blood vessels to feed themselves.</p> <p>To learn how HIF-1?'s own activity is controlled, the team looked for proteins from human cells that would attach to HIF-1?. They found two, MCM3 and MCM7, that limited HIF-1?'s activity, and were also part of the DNA replication machinery. Those results were reported in 2011.</p> <p>In the new research, Semenza and his colleagues further probed HIF-1?'s relationship to DNA replication by comparing cells in low-oxygen conditions to cells kept under normal conditions. They measured the amount of DNA replication complexes in the cells, as well as how active the complexes were. The cells kept in low-oxygen conditions, which had stopped dividing, had just as much of the DNA replication machinery as the normal dividing cells, the researchers found; the difference was that the machinery wasn't working. It turned out that in the nondividing cells, HIF-1? was binding to a protein that loads the DNA replication complex onto DNA strands, and preventing the complex from being activated.</p> <p>"Our experiments answered the long-standing question of how, exactly, cells stop dividing in response to low oxygen," says Maimon Hubbi, Ph.D., a member of Semenza's team who is now working toward an M.D. degree. "It also shows us that the relationship between HIF-1? and the DNA replication complex is reciprocal -- that is, each can shut the other down."</p> <p><em>Share this story on <strong>Facebook</strong>, <strong>Twitter</strong>, and <strong>Google</strong>:</em></p> <p><em>Other social bookmarking and sharing tools:</em></p> <hr /><p><strong>Story Source:</strong></p> <blockquote readability="10.4034334764"><p>The above story is reprinted from materials provided by <strong><span id="source">Johns Hopkins Medicine</span></strong>, via EurekAlert!, a service of AAAS. </p> <p><em>Note: Materials may be edited for content and length. For further information, please contact the source cited above.</em></p></blockquote> <hr /><p><strong>Journal Reference</strong>:</p> <ol><li>M. E. Hubbi, Kshitiz, D. M. Gilkes, S. Rey, C. C. Wong, W. Luo, D.-H. Kim, C. V. Dang, A. Levchenko, G. L. Semenza. <strong>A Nontranscriptional Role for HIF-1? as a Direct Inhibitor of DNA Replication</strong>. <em>Science Signaling</em>, 2013; 6 (262): ra10 DOI: 10.1126/scisignal.2003417</li> </ol> <p><em>Note: If no author is given, the source is cited instead.</em></p> <p><em><strong>Disclaimer</strong>: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.</em></p><p>Source: <a href="http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/XQflXj1NWK4/130223111517.htm">http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/XQflXj1NWK4/130223111517.htm</a></p><p><a href="http://www.virtualurth.com/index.php/member/120017/">Rise of the Guardians</a> <a href="http://www.myeclipseide.com/user.php?op=userinfo&uname=regioscast">Pumpkin Pie</a> <a href="http://baijia.info/member.php?action=profile&uid=63378">Jack Taylor</a> <a href="http://mbdefault.org/forum/member.php?action=profile&uid=30232">Apple Pie Recipe</a> <a href="http://www.spidean.com/user.php?op=userinfo&uname=regioscast">black friday</a> <a href="http://www.nameslot.com/member.php?action=profile&uid=13708">How long to cook a turkey</a> <a href="http://www.fortunesalwayshiding.net/forum/member.php?action=profile&uid=83946">green bean casserole</a> </p>
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